Truncated reverse isoxazolidinyl nucleosides: a new class of allosteric HIV-1 reverse transcriptase inhibitors

ChemMedChem. 2012 Apr;7(4):565-9. doi: 10.1002/cmdc.201200022. Epub 2012 Feb 9.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Avian Myeloblastosis Virus / enzymology
  • Cell-Free System
  • Drug Evaluation, Preclinical / methods
  • HIV Reverse Transcriptase / antagonists & inhibitors*
  • HIV Reverse Transcriptase / chemistry
  • HIV Reverse Transcriptase / metabolism
  • Humans
  • Microbial Sensitivity Tests
  • Models, Molecular
  • Molecular Structure
  • Nevirapine / pharmacology
  • Nucleosides / chemical synthesis*
  • Nucleosides / chemistry
  • Nucleosides / pharmacology
  • RNA-Directed DNA Polymerase / metabolism
  • Reverse Transcriptase Inhibitors / chemistry*
  • Reverse Transcriptase Inhibitors / pharmacology*
  • T-Lymphocytes / drug effects
  • Tyrosine / chemistry
  • Tyrosine / metabolism

Substances

  • Nucleosides
  • Reverse Transcriptase Inhibitors
  • Tyrosine
  • Nevirapine
  • reverse transcriptase, Human immunodeficiency virus 1
  • HIV Reverse Transcriptase
  • RNA-Directed DNA Polymerase