Several recent reviews have reported that 'repetitive movements' is a risk factor for occupational musculoskeletal disorders (MSD) in the neck, shoulder and arm regions. More variation in biomechanical exposure is often suggested as an effective intervention in such settings. While increasing variation using extrinsic methods like job rotation may not always be possible in an industrial context, the intrinsic variability of the motor system may offer an alternative opportunity to increase variation. Motor variability (MV) refers to the natural variation in postures, movements and muscle activity observed to different extents in all tasks. The current review explores the state of the art in MV research from motor control, sports and occupational biomechanics literature to answer whether MV is important to consider in an occupational context, and if yes, whether this literature stimulates further studies to test if MV can be manipulated as a deliberate intervention for increasing biomechanical variation without jeopardizing production.