A "one-pot" multicomponent approach to polysubstituted 4-aminopyridines

Chem Commun (Camb). 2012 Mar 14;48(22):2785-7. doi: 10.1039/c2cc17850h. Epub 2012 Feb 7.

Abstract

A novel and facile domino reaction has been developed to synthesize a variety of polysubstituted 4-aminopyridines from α-azidovinylketones, aldehydes and methylamine derivatives in reasonably good yields under mild conditions. Additionally, a possible mechanism is proposed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 4-Aminopyridine / chemical synthesis
  • 4-Aminopyridine / chemistry*
  • Aldehydes / chemistry
  • Crystallography, X-Ray
  • Ketones / chemistry
  • Methylamines / chemistry
  • Molecular Conformation

Substances

  • Aldehydes
  • Ketones
  • Methylamines
  • 4-Aminopyridine
  • methylamine