Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum

Mohamed-Elamir F Hegazy; Ahmed A El-Beih; Alaa Y Moustafa; Abdelhamed A Hamdy; Montaser A Alhammady; Rehab M Selim; Mohamed Abdel-Rehim; Paul W Paré

Cytotoxic cembranoids from the Red Sea soft coral Sarcophyton glaucum

Nat Prod Commun. 2011 Dec;6(12):1809-12.

Authors

Mohamed-Elamir F Hegazy¹, Ahmed A El-Beih, Alaa Y Moustafa, Abdelhamed A Hamdy, Montaser A Alhammady, Rehab M Selim, Mohamed Abdel-Rehim, Paul W Paré

Affiliation

¹ Chemistry of Medicinal Plants Department, National Research Centre, Dokki, Giza 12622, Egypt.

PMID: 22312712

Abstract

One new cembrane diterpene, 2R,7R,8R-dihydroxydeepoxysarcophine (1), together with three known compounds, 7alpha,8beta-dihydroxydeepoxysarcophine (2), 7beta-acetoxy-8alpha-hydroxydeepoxysarcophine (3), and sarcophine (4), have been isolated from the Red Sea soft coral Sarcophyton glaucum. Their structures were determined using 1D and 2D NMR spectroscopy. 7beta-Acetoxy-8alpha-hydroxydeepoxysarcophine (3) exhibits cytotoxic activity against HepG2, HCT-116, and HeLa cells with IC50 values of 3.6, 2.3, and 6.7 microg/mL, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Antineoplastic Agents / isolation & purification*
Cell Line, Tumor
Cell Survival / drug effects
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology
Humans
Molecular Conformation

Substances

Antineoplastic Agents
Diterpenes