Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers

Brieuc Guillerm; Vincent Darcos; Vincent Lapinte; Sophie Monge; Jean Coudane; Jean-Jacques Robin

doi:10.1039/c2cc30191a

Synthesis and evaluation of triazole-linked poly(ε-caprolactone)-graft-poly(2-methyl-2-oxazoline) copolymers as potential drug carriers

Chem Commun (Camb). 2012 Mar 18;48(23):2879-81. doi: 10.1039/c2cc30191a. Epub 2012 Feb 7.

Authors

Brieuc Guillerm¹, Vincent Darcos, Vincent Lapinte, Sophie Monge, Jean Coudane, Jean-Jacques Robin

Affiliation

¹ Institut Charles Gerhardt Montpellier UMR5253 CNRS-UM2-ENSCM-UM1-Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier II cc1702, Place Eugène Bataillon, 34095 Montpellier, France.

PMID: 22311101
DOI: 10.1039/c2cc30191a

Abstract

Well-defined graft copolymers were obtained using a copper-catalysed azide-alkyne Huisgen's cycloaddition click reaction from both biocompatible and non-toxic poly(ε-caprolactone) and poly(2-methyl-2-oxazoline) homopolymers. Resulting amphiphilic copolymers proved to form micelles that could be used as potential drug carriers.

MeSH terms

Alkynes / chemistry
Azides / chemistry
Catalysis
Click Chemistry
Copper / chemistry
Drug Carriers / chemistry*
Micelles
Polyamines / chemistry*
Polyesters / chemistry*
Polymers / chemical synthesis*
Polymers / chemistry
Triazoles / chemistry*

Substances

Alkynes
Azides
Drug Carriers
Micelles
Polyamines
Polyesters
Polymers
Triazoles
poly(2-methyl-2-oxazoline)
polycaprolactone
Copper