Abstract
LUBAC (linear ubiquitin chain assembly complex) is a ubiquitin ligase complex composed of SHARPIN, HOIL-IL and HOIP that generates linear polyubiquitin chains and regulates the NF-κB pathway, which is pivotal in inflammatory and immune responses. Recent findings on the regulation of NF-κB by LUBAC and the diseases associated with this process are the focus of this review.
Copyright © 2012 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptive Immunity / physiology*
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Animals
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Carrier Proteins / immunology*
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Humans
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Inflammation / enzymology*
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Inflammation / immunology*
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Intracellular Signaling Peptides and Proteins
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Mice
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NF-kappa B / immunology*
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Ubiquitin-Protein Ligases / immunology*
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Ubiquitination
Substances
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Carrier Proteins
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HOIL-1L protein, mouse
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Intracellular Signaling Peptides and Proteins
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NF-kappa B
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Sipl1 protein, mouse
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Rnf31 protein, mouse
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Ubiquitin-Protein Ligases