Infections in humans are related with changes in the environment specially those associated with food, water, and vectors. Changes in the environment are also related to epidemics, however this relationship has not been clarified, and multiple factors additional to climate changes may be involved in the pathogenesis of epidemics. Therefore, several predictive epidemiological models have been developed with the aim to determine the degree of sensitivity of different diseases to climate changes, and their association with outbreaks to plan prevention strategies.