Common variants at 11p13 are associated with susceptibility to tuberculosis

Nat Genet. 2012 Feb 5;44(3):257-9. doi: 10.1038/ng.1080.

Abstract

After imputation of data from the 1000 Genomes Project into a genome-wide dataset of Ghanaian individuals with tuberculosis and controls, we identified a resistance locus on chromosome 11p13 downstream of the WT1 gene (encoding Wilms tumor 1). The strongest signal was obtained at the rs2057178 SNP (P = 2.63 × 10(-9)). Replication in Gambian, Indonesian and Russian tuberculosis case-control study cohorts increased the significance level for the association with this SNP to P = 2.57 × 10(-11).

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Cell Cycle Proteins
  • Chromosomes, Human, Pair 11 / genetics*
  • Cohort Studies
  • Genetic Predisposition to Disease / genetics*
  • Genetic Variation / genetics*
  • Genotype
  • Ghana
  • Humans
  • Models, Genetic
  • Nuclear Proteins / genetics
  • Polymorphism, Single Nucleotide / genetics
  • RNA Splicing Factors
  • Tuberculosis / genetics*

Substances

  • Cell Cycle Proteins
  • Nuclear Proteins
  • RNA Splicing Factors
  • WTAP protein, human