Abstract
In this work, we produced and evaluated a vaccine based on a β toxoid of Clostridium perfringens type C produced in Escherichia coli (rBT). The non-toxic rBT was innocuous for mice and induced 14 IU mL(-1) of β antitoxin in rabbits, complying with the European Pharmacopeia and CFR9 - USDA guidelines.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacterial Toxins / genetics
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Bacterial Vaccines / biosynthesis*
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Bacterial Vaccines / genetics
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Bacterial Vaccines / toxicity
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Clostridium perfringens / immunology*
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Escherichia coli
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Mice
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Mice, Inbred BALB C
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Rabbits
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Toxoids / biosynthesis*
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Toxoids / genetics
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Toxoids / toxicity
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Vaccination
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Vaccines, Synthetic / biosynthesis*
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Vaccines, Synthetic / genetics
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Vaccines, Synthetic / toxicity
Substances
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Bacterial Toxins
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Bacterial Vaccines
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Toxoids
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Vaccines, Synthetic