Syntheses of structurally-simplified and fluorescently-labeled neovibsanin derivatives and analysis of their neurite outgrowth activity in PC12 cells

Bioorg Med Chem Lett. 2012 Mar 1;22(5):2089-93. doi: 10.1016/j.bmcl.2012.01.006. Epub 2012 Jan 11.

Abstract

The syntheses of several neovibsanin derivatives were carried out in order to elucidate the simple structure required for displaying neurite outgrowth activity. In addition, a fluorescent probe molecule was synthesized and the analysis of its behavior in the PC12 cell line showed that the neovibsanins accumulate on the outer edge of the cell at the site of formation of prominences.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Diterpenes / analysis
  • Diterpenes / chemical synthesis
  • Diterpenes / chemistry*
  • Diterpenes / pharmacology*
  • Fluorescent Dyes / chemistry
  • Models, Molecular
  • Neurites / drug effects*
  • Neurites / ultrastructure
  • Neurogenesis / drug effects*
  • Neurons / cytology*
  • Neurons / drug effects
  • Neurons / ultrastructure
  • PC12 Cells
  • Rats
  • Viburnum / chemistry*

Substances

  • Diterpenes
  • Fluorescent Dyes