Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system

Ivan M Ryzhov; Elena Yu Korchagina; Inna S Popova; Nicolai V Bovin

doi:10.1016/j.carres.2011.12.013

Block synthesis of A tetrasaccharides (types 1, 3, and 4) related to the human ABO blood group system

Carbohydr Res. 2012 Apr 1:351:17-25. doi: 10.1016/j.carres.2011.12.013. Epub 2011 Dec 24.

Authors

Ivan M Ryzhov¹, Elena Yu Korchagina, Inna S Popova, Nicolai V Bovin

Affiliation

¹ Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, Moscow 117997, Russian Federation.

PMID: 22305408
DOI: 10.1016/j.carres.2011.12.013

Abstract

Blood group A tetrasaccharides of different types have the same terminal trisaccharide fragment that allows using a block scheme in their synthesis. 3-Aminopropyl glycosides of tetrasaccharides GalNAcα1-3(Fucα1-2)Galβ1-3GlcNAcβ (A type 1), GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcα (A type 3), and GalNAcα1-3(Fucα1-2)Galβ1-3GalNAcβ (A type 4) were synthesised using acetylated Galα1-3(Fucα1-2)Gal trichloroacetimidate as a glycosyl donor at the key stage.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

ABO Blood-Group System / chemistry*
Carbohydrate Sequence
Chemistry Techniques, Synthetic*
Humans
Molecular Sequence Data
Oligosaccharides / chemical synthesis*
Oligosaccharides / chemistry*

Substances

ABO Blood-Group System
Oligosaccharides