Mannose-binding lectin and Toll-like receptor polymorphisms and Chagas disease in Chile

Am J Trop Med Hyg. 2012 Feb;86(2):229-32. doi: 10.4269/ajtmh.2012.11-0539.

Abstract

Mannose-binding lectin (MBL) and Toll-like receptor (TLR) polymorphisms may influence susceptibility and manifestation of Trypanosoma cruzi infection. In northern Chile, we examined 61 asymptomatic patients with chronic Chagas disease (CD), 64 patients with chronic Chagas cardiomyopathy (CCC), and 45 healthy individuals. Low-producer MBL2*B genotypes were more common in CD patients (48%) than healthy individuals (31%; adjusted odds ratio = 2.3, 95% confidence interval = 1.01-5.4, P = 0.047) but did not differ with manifestation. In contrast, the heterozygous Toll-like receptor 4 (TLR4)-deficiency genotype D299G/T399I occurred more frequently in asymptomatic (14.8%) than CCC patients (3.1%; P = 0.02). TLR1-I602S, TLR2-R753Q, TLR6-S249P, and MAL/TIRAP-S180L did not associate with CD or CCC. These findings support the complement system to be involved in defense against Trypanosoma cruzi infection and indicate that curbed TLR4 activation might be beneficial in preventing CCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Case-Control Studies
  • Chagas Cardiomyopathy / epidemiology*
  • Chagas Cardiomyopathy / genetics*
  • Chagas Cardiomyopathy / immunology
  • Child
  • Child, Preschool
  • Chile / epidemiology
  • Chronic Disease
  • Disease Susceptibility
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genotype
  • Heterozygote
  • Humans
  • Immunity, Innate
  • Infant
  • Male
  • Mannose-Binding Lectin / genetics*
  • Mannose-Binding Lectin / metabolism
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Toll-Like Receptor 4 / genetics*
  • Toll-Like Receptor 4 / metabolism
  • Young Adult

Substances

  • MBL2 protein, human
  • Mannose-Binding Lectin
  • TLR4 protein, human
  • Toll-Like Receptor 4