Abstract
A concise synthetic route has been developed for the preparation of a constrained peptidomimetic pyrazinone building block. From hydroxy-L-lysine, the desired pyrazinone is obtained in 43% overall yield (6 steps) via an efficient deprotection-double cyclization sequence.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemistry Techniques, Synthetic
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Cyclization
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Peptidomimetics / chemical synthesis
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Peptidomimetics / chemistry*
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Pyrazines / chemical synthesis
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Pyrazines / chemistry*
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Stereoisomerism
Substances
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Peptidomimetics
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Pyrazines