Abstract
Sequestosome 1/p62 is a signal modulator or adaptor protein involved in receptor-mediated signal transduction. Sequestosome 1/p62 is gaining attention as it is involved in several diseases including Parkinson disease, Alzheimer disease, liver and breast cancer, Paget's disease of bone, obesity and insulin resistance. In this review, we will focus on the most recent advances on the physiological function of p62 relevant to human diseases.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing* / genetics
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Adaptor Proteins, Signal Transducing* / metabolism
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Animals
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Diabetes Mellitus, Type 2 / metabolism
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Diabetes Mellitus, Type 2 / physiopathology
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Gene Expression
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Humans
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Insulin Resistance
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Mice
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Mice, Knockout
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Neoplasms / metabolism
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Neoplasms / physiopathology
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Neurodegenerative Diseases / metabolism
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Neurodegenerative Diseases / physiopathology
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Obesity / metabolism
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Obesity / physiopathology
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Osteitis Deformans / metabolism
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Osteitis Deformans / physiopathology
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Sequestosome-1 Protein
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Signal Transduction*
Substances
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Adaptor Proteins, Signal Transducing
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SQSTM1 protein, human
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Sequestosome-1 Protein