The literatures of clinical application showed that Xiaoke pill has exact effect on type 2 diabetes. Because Xiaoke pills contain glyburide, most adverse reactions are resulted from inappropriate use. Clinical scientific and medical treatment can be guided by strengthening the mission, improving the instructions of medicines, improving pharmaceutical production technology, strengthening clinical research to further explore the relationship between blood glucose levels and dose, and clearing indications and contraindications. These also can improve security together with the good economy, and will benefit the sustainable development of Xiaoke pill.