Abstract
Basonuclins 1 and 2 are nuclear proteins specific to vertebrates. They have recently been shown to be the orthologs of the DISCO proteins of insects. All of these proteins have an essential function in embryonic development. It is likely that they are transcription factors with multiple gene targets, some of which are transcribed by DNA polymerase I, and others by polymerase II. It remains to be found which targets are common to the two basonuclins and even to the DISCO proteins, and why certain cell types possess either basonuclin 1 or basonuclin 2, while others possess both. The implication of the basonuclins in several human diseases adds to their interest as regulatory proteins.
© 2012 médecine/sciences – Inserm / SRMS.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Cell Division / genetics
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Cell Division / physiology
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Consensus Sequence
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Drosophila Proteins / chemistry
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Drosophila Proteins / physiology
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Embryo, Nonmammalian / metabolism
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Embryonic Development / genetics
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Embryonic Development / physiology
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Gene Expression Regulation, Developmental*
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Humans
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Insect Proteins / genetics
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Insect Proteins / physiology*
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Insecta / embryology*
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Insecta / genetics
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Molecular Sequence Data
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Multigene Family
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Neoplasm Proteins / genetics
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Neoplasm Proteins / physiology
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Sequence Alignment
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Sequence Homology, Amino Acid
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / physiology*
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Vertebrates / embryology*
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Vertebrates / genetics
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Zinc Fingers / genetics
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Zinc Fingers / physiology
Substances
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DNA-Binding Proteins
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Drosophila Proteins
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Insect Proteins
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Neoplasm Proteins
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Transcription Factors
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disco protein, Drosophila