A strong two-photon induced phosphorescent Golgi-specific in vitro marker based on a heteroleptic iridium complex

C-L Ho; K-L Wong; H-K Kong; Y-M Ho; C T-L Chan; W-M Kwok; K S-Y Leung; H-L Tam; M H-W Lam; X-F Ren; A-M Ren; J-K Feng; W-Y Wong

doi:10.1039/c2cc16993b

A strong two-photon induced phosphorescent Golgi-specific in vitro marker based on a heteroleptic iridium complex

Chem Commun (Camb). 2012 Mar 4;48(19):2525-7. doi: 10.1039/c2cc16993b. Epub 2012 Jan 30.

Authors

C-L Ho¹, K-L Wong, H-K Kong, Y-M Ho, C T-L Chan, W-M Kwok, K S-Y Leung, H-L Tam, M H-W Lam, X-F Ren, A-M Ren, J-K Feng, W-Y Wong

Affiliation

¹ Department of Chemistry and Institute of Advanced Materials, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.

PMID: 22288076
DOI: 10.1039/c2cc16993b

Abstract

A new heteroleptic iridium complex demonstrated low cytotoxicity and near-infrared excitation (via two-photon absorption) for target-specific in vitro Golgi imaging in various cell lines (HeLa and A549 cells) with two-photon absorption cross section (~350 GM) in DMSO.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Golgi Apparatus / drug effects
Golgi Apparatus / metabolism*
HeLa Cells
Humans
Iridium / chemistry*
Luminescent Agents / chemical synthesis
Luminescent Agents / chemistry*
Luminescent Agents / metabolism*
Luminescent Agents / toxicity
Organometallic Compounds / chemical synthesis
Organometallic Compounds / chemistry*
Organometallic Compounds / metabolism*
Organometallic Compounds / toxicity
Photons*

Substances

Luminescent Agents
Organometallic Compounds
Iridium