Abstract
A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Adult
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Biomechanical Phenomena
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Cerebral Cortex / physiology
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Data Interpretation, Statistical
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Female
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Gait Disorders, Neurologic / physiopathology*
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Hand / physiology
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Humans
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Image Processing, Computer-Assisted
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Imaging, Three-Dimensional
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Models, Neurological*
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Motor Skills / physiology
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Movement / physiology
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Neuronavigation / instrumentation
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Neuronavigation / methods
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Psychomotor Performance / physiology
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Transcranial Magnetic Stimulation
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User-Computer Interface