Towards a healthy human model of neural disorders of movement

IEEE Trans Neural Syst Rehabil Eng. 2012 Nov;20(6):853-7. doi: 10.1109/TNSRE.2012.2184769. Epub 2012 Jan 23.

Abstract

A quantitative approach to virtual-lesion physiology is presented which integrates event-related fMRI, image-guided, repetitive, transcranial magnetic stimulation (irTMS), and simultaneous recording of 3-D movement kinematics. By linking motor neuroscience with clinical disorders of motor function, our method allows development of a healthy, human system model of disorders of skilled action.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Biomechanical Phenomena
  • Cerebral Cortex / physiology
  • Data Interpretation, Statistical
  • Female
  • Gait Disorders, Neurologic / physiopathology*
  • Hand / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Models, Neurological*
  • Motor Skills / physiology
  • Movement / physiology
  • Neuronavigation / instrumentation
  • Neuronavigation / methods
  • Psychomotor Performance / physiology
  • Transcranial Magnetic Stimulation
  • User-Computer Interface