Macrophage activation syndrome following Acinetobacter baumannii sepsis

Teny Mathew John; Ceena N Jacob; Cherian C Ittycheria; Amrutha M George; Amith G Jacob; Saji Subramaniyam; Jabbar Puthiyaveettil; R Jayaprakash

doi:10.1016/j.ijid.2011.12.002

Macrophage activation syndrome following Acinetobacter baumannii sepsis

Int J Infect Dis. 2012 Mar;16(3):e223-4. doi: 10.1016/j.ijid.2011.12.002. Epub 2012 Jan 27.

Authors

Teny Mathew John¹, Ceena N Jacob, Cherian C Ittycheria, Amrutha M George, Amith G Jacob, Saji Subramaniyam, Jabbar Puthiyaveettil, R Jayaprakash

Affiliation

¹ Department of Internal Medicine, Government Medical College, Kottayam, Kerala, 686008, India. teny007@gmail.com

PMID: 22285540
DOI: 10.1016/j.ijid.2011.12.002

Abstract

Macrophage activation syndrome (MAS) is a systemic disorder with a high mortality, commonly associated with rheumatological conditions, but which can also occur as a complication of several infections. Here we present a case of MAS following Acinetobacter baumannii sepsis. Early institution of therapy with prednisolone, cyclosporine, colistin, and polymyxin resulted in a prompt clinical recovery. There are very few reported cases of Acinetobacter-related MAS that have been successfully treated.

Publication types

Case Reports

MeSH terms

Acinetobacter Infections / complications*
Acinetobacter Infections / drug therapy
Acinetobacter baumannii / drug effects
Acinetobacter baumannii / pathogenicity*
Adult
Anti-Bacterial Agents / therapeutic use
Colistin / therapeutic use
Cyclosporine / therapeutic use
Drug Resistance, Multiple, Bacterial
Humans
Macrophage Activation Syndrome / complications
Macrophage Activation Syndrome / microbiology*
Male
Polymyxins / therapeutic use
Prednisolone / therapeutic use
Sepsis / complications*
Sepsis / drug therapy
Sepsis / microbiology

Substances

Anti-Bacterial Agents
Polymyxins
Cyclosporine
Prednisolone
Colistin