Abstract
The short multiepitopic synthetic peptides from the sequences of hypervariable area of V3-loope of gp120 of HIV don't induce anti-peptides antibodies production in mice themselves. We prepared the potent immunogen by noncovalent conjugations of the multitude peptides with pure peptidoglycans from cell wall of Salmonella typhi. The sera from immunized mice have the anti-peptides antibody titers (3-5) x 10(5) in ELISA, as high as Freund's adjuvant is of use.
MeSH terms
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AIDS Vaccines / chemical synthesis
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AIDS Vaccines / immunology
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AIDS Vaccines / pharmacology*
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Adjuvants, Immunologic / chemical synthesis
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Adjuvants, Immunologic / pharmacology*
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Antibodies, Viral / blood
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Antibodies, Viral / immunology
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HIV Envelope Protein gp120 / chemical synthesis
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HIV Envelope Protein gp120 / immunology
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HIV Envelope Protein gp120 / pharmacology*
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Peptides
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Peptidoglycan / chemistry
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Peptidoglycan / immunology
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Peptidoglycan / pharmacology*
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Salmonella typhi / chemistry*
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Salmonella typhi / immunology
Substances
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AIDS Vaccines
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Adjuvants, Immunologic
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Antibodies, Viral
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HIV Envelope Protein gp120
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Peptides
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Peptidoglycan