Abstract
Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolutionmass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and antibacterial activities.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents* / chemistry
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Anti-Bacterial Agents* / isolation & purification
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Anti-Bacterial Agents* / pharmacology
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Drug Screening Assays, Antitumor
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Hep G2 Cells
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Humans
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Italy
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Microbial Sensitivity Tests
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Molecular Structure
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Myrtus / chemistry*
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Phloroglucinol / analogs & derivatives
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Phloroglucinol / chemistry
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Phloroglucinol / isolation & purification*
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Phloroglucinol / pharmacology
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Plant Leaves / chemistry
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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myrtucommulone A
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Phloroglucinol