Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp

Gang Li; Haiying Wang; Rongxiu Zhu; Lingmei Sun; Lining Wang; Ming Li; Yaoyao Li; Yongqing Liu; Zuntian Zhao; Hongxiang Lou

doi:10.1021/np200614h

Phaeosphaerins A-F, cytotoxic perylenequinones from an endolichenic fungus, Phaeosphaeria sp

J Nat Prod. 2012 Feb 24;75(2):142-7. doi: 10.1021/np200614h. Epub 2012 Jan 25.

Authors

Gang Li¹, Haiying Wang, Rongxiu Zhu, Lingmei Sun, Lining Wang, Ming Li, Yaoyao Li, Yongqing Liu, Zuntian Zhao, Hongxiang Lou

Affiliation

¹ Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, People's Republic of China.

PMID: 22276650
DOI: 10.1021/np200614h

Abstract

Six novel phototoxins, phaeosphaerins A-F, together with six known perylenequinones were isolated from an endolichenic fungus Phaeosphaeria sp. Their structures were determined unequivocally on the basis of comprehensive analysis of MS and NMR data as well as electronic circular dichroism calculations. These toxins kill cancer cells in vitro with accumulation in lysosomes, and the killing effects were potently intensified in the presence of light.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Antineoplastic Agents* / chemistry
Antineoplastic Agents* / isolation & purification
Antineoplastic Agents* / pharmacology
Ascomycota / chemistry*
Drug Screening Assays, Antitumor
Humans
K562 Cells
Lysosomes / metabolism
Male
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Perylene* / analogs & derivatives
Perylene* / chemistry
Perylene* / isolation & purification
Perylene* / pharmacology

Substances

Antineoplastic Agents
Perylene