Antitumor cyclic hexapeptides from rubia plants: history, chemistry, and mechanism (2005-2011)

Chimia (Aarau). 2011;65(12):952-6. doi: 10.2533/chimia.2011.952.

Abstract

Rubiaceae-type cyclopeptides (RAs), cyclic hexapeptides from Rubia plants, have shown potential antitumor activity in vitro and in vivo. Based on the review about plant cyclopeptides (Chem. Rev., 2006, 106: 840), this mini-review will highlight new progress on the discovery, synthesis, and mechanism of RAs isolated during 2005 to 2011, covering recent work in our group.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification*
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Cells, Cultured
  • Humans
  • Oligopeptides / chemistry
  • Oligopeptides / isolation & purification*
  • Oligopeptides / pharmacology
  • Peptides, Cyclic / chemistry
  • Peptides, Cyclic / isolation & purification*
  • Peptides, Cyclic / pharmacology
  • Rubia / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Oligopeptides
  • Peptides, Cyclic