The role of the E2F transcription factor family in UV-induced apoptosis

Mehlika Hazar-Rethinam; Liliana Endo-Munoz; Orla Gannon; Nicholas Saunders

doi:10.3390/ijms12128947

The role of the E2F transcription factor family in UV-induced apoptosis

Int J Mol Sci. 2011;12(12):8947-60. doi: 10.3390/ijms12128947. Epub 2011 Dec 6.

Authors

Mehlika Hazar-Rethinam¹, Liliana Endo-Munoz, Orla Gannon, Nicholas Saunders

Affiliation

¹ Epithelial Pathobiology Group, University of Queensland Diamantina Institute, Princess Alexandra Hospital, Queensland 4102, Australia. m.rethinam@uq.edu.au

Abstract

The E2F transcription factor family is traditionally associated with cell cycle control. However, recent data has shown that activating E2Fs (E2F1-3a) are potent activators of apoptosis. In contrast, the recently cloned inhibitory E2Fs (E2F7 and 8) appear to antagonize E2F-induced cell death. In this review we will discuss (i) the potential role of E2Fs in UV-induced cell death and (ii) the implications of this to the development of UV-induced cutaneous malignancies.

Keywords: E2F; UV; apoptosis; sunburn cells.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Apoptosis*
E2F Transcription Factors / chemistry
E2F Transcription Factors / genetics
E2F Transcription Factors / metabolism*
Humans
Keratinocytes / metabolism
Keratinocytes / pathology
Keratinocytes / physiology
Skin Neoplasms / etiology
Skin Neoplasms / metabolism*
Ultraviolet Rays / adverse effects*

Substances

E2F Transcription Factors