Abstract
A bioassay-guided fractionation and chemical investigation of a MeOH extract of the Korean wild mushroom Boletus pseudocalopus resulted in the identification of three new fatty acid esters, named calopusins A-C (1-3), along with two known fatty acid methyl esters (4-5). These new compounds are structurally unique fatty acid esters with a 2,3-butanediol moiety. Their structures were elucidated through 1D- and 2D-NMR spectroscopic data and GC-MS analysis as well as a modified Mosher's method. The new compounds 1-3 showed significant inhibitory activity against the proliferation of the tested cancer cell lines with IC(50) values in the range 2.77-12.51 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Basidiomycota / chemistry*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Etoposide / pharmacology
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Fatty Acids / chemistry
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Fatty Acids / isolation & purification*
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Fatty Acids / pharmacology
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Fatty Acids, Monounsaturated / chemistry
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Fatty Acids, Monounsaturated / isolation & purification*
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Fatty Acids, Monounsaturated / pharmacology
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Fruiting Bodies, Fungal / chemistry*
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Human Umbilical Vein Endothelial Cells / drug effects
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Human Umbilical Vein Endothelial Cells / physiology
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Humans
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Hydrolysis
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Inhibitory Concentration 50
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Quantum Theory
Substances
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Antineoplastic Agents
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Fatty Acids
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Fatty Acids, Monounsaturated
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calopusin A
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calopusin B
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calopusin C
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Etoposide