Abstract
Triptolide, a principal bioactive ingredient of Tripterygium wilfordii Hook F, has attracted extensive exploration due to its unique structure of a diterpenoid triepoxide and multiple biological activities. This review will focus on the structural modifications, structure-activity relationships, pharmacology, and clinical development of triptolide in the last forty years.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal* / chemistry
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Anti-Inflammatory Agents, Non-Steroidal* / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal* / pharmacology
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Diterpenes* / chemistry
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Diterpenes* / isolation & purification
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Diterpenes* / pharmacology
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Epoxy Compounds / chemistry
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Epoxy Compounds / isolation & purification
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Epoxy Compounds / pharmacology
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Molecular Structure
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Phenanthrenes* / chemistry
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Phenanthrenes* / isolation & purification
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Phenanthrenes* / pharmacology
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Structure-Activity Relationship
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Tripterygium / chemistry*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Diterpenes
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Epoxy Compounds
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Phenanthrenes
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triptolide