Isostreptazolin and sannaphenol, two new metabolites from Streptomyces sannanensis

Dan Zheng; Li Han; Yiqing Li; Jun Li; He Rong; Qiao Leng; Yi Jiang; Lixing Zhao; Xueshi Huang

doi:10.3390/molecules17010836

Isostreptazolin and sannaphenol, two new metabolites from Streptomyces sannanensis

Molecules. 2012 Jan 16;17(1):836-42. doi: 10.3390/molecules17010836.

Authors

Dan Zheng¹, Li Han, Yiqing Li, Jun Li, He Rong, Qiao Leng, Yi Jiang, Lixing Zhao, Xueshi Huang

Affiliation

¹ Ministry of Health Key Laboratory of Congenital Malformation, Laboratory of Metabolic Disease Research and Drug Development, China Medical University, Shenyang, China.

Abstract

Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis and their structures elucidated on the basis of 1D and 2D NMR as well as MS, IR and UV spectroscopic data analysis. The cytotoxic activity of 1 and 2 were evaluated. Both compounds were inactive against H460 and HeLa cell lines at 100 mM.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Drug Screening Assays, Antitumor
Humans
Magnetic Resonance Spectroscopy
Phenols / chemistry
Phenols / isolation & purification*
Phenols / pharmacology
Piperidines / chemistry
Piperidines / isolation & purification*
Piperidines / pharmacology
Streptomyces / metabolism*

Substances

Phenols
Piperidines
streptazolin