Age-related features of expression of cell renewal factors in the intestinal Peyer's patches

L A Grabezhev; N N Sevostjanova; A N Kolmakov; S S Konovalov; V O Polyakova; I M Kvetnoy

doi:10.1007/s10517-011-1169-3

Age-related features of expression of cell renewal factors in the intestinal Peyer's patches

Bull Exp Biol Med. 2011 Feb;150(4):465-7. doi: 10.1007/s10517-011-1169-3.

Authors

L A Grabezhev¹, N N Sevostjanova, A N Kolmakov, S S Konovalov, V O Polyakova, I M Kvetnoy

Affiliation

¹ St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of the Russian Academy of Medical Sciences, Russia.

PMID: 22268044
DOI: 10.1007/s10517-011-1169-3

Abstract

Immunohistochemical study with markers of proapoptotic protein P53 and proliferation protein Ki-67 revealed an age-related decrease in proliferative activity of lymphocyte in the intestinal Peyer's patches and an increase in the ratio of apoptotic cells in humans. These changes aggravate atrophy and involution of the intestinal epithelium during aging.

MeSH terms

Aging*
Apoptosis
Cell Proliferation
Humans
Immunohistochemistry
Intestinal Mucosa / metabolism
Intestinal Mucosa / pathology
Intestinal Mucosa / physiology
Intestines / cytology
Ki-67 Antigen / metabolism*
Lymphocytes / cytology
Lymphocytes / metabolism
Peyer's Patches / cytology*
Peyer's Patches / metabolism
Tumor Suppressor Protein p53 / metabolism*

Substances

Ki-67 Antigen
TP53 protein, human
Tumor Suppressor Protein p53