Biologically triggered exploding protein based microcapsules for drug delivery

Chem Commun (Camb). 2012 Feb 25;48(17):2307-9. doi: 10.1039/c2cc17344a. Epub 2012 Jan 23.

Abstract

Biologically triggered exploding microcapsules were synthesized by layer-by-layer assembly of biopolymers. The microcapsules showed controlled rupturing behaviour upon exposure to a pathologically relevant biomolecule, trypsin. These microcapsules offer significant potential for clinical applications.

MeSH terms

  • Biopolymers / chemistry
  • Capsules / chemistry*
  • Drug Carriers / chemistry*
  • Hydrogen-Ion Concentration
  • Trypsin / chemistry
  • Trypsin / metabolism*

Substances

  • Biopolymers
  • Capsules
  • Drug Carriers
  • Trypsin