Abstract
There have been encouraging recent successes in the development of safe and effective topical microbicides to prevent vaginal or rectal HIV-1 transmission, based on the use of anti-retroviral drugs. However, much work remains to be accomplished before a microbicide becomes a standard element of prevention science strategies. Animal models should continue to play an important role in pre-clinical testing, with emphasis on safety, pharmacokinetic and efficacy testing.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Administration, Topical
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Animals
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Anti-Infective Agents, Local / administration & dosage
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Anti-Infective Agents, Local / therapeutic use*
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Anti-Retroviral Agents / administration & dosage
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Anti-Retroviral Agents / therapeutic use*
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Disease Models, Animal*
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Drug Evaluation, Preclinical
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HIV Infections / prevention & control*
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HIV Infections / transmission
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HIV-1 / drug effects*
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Macaca mulatta
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Mice
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Rabbits
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Rats
Substances
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Anti-Infective Agents, Local
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Anti-Retroviral Agents