A clean procedure for synthesis of pyrido[d]pyrimidine derivatives under solvent-free conditions catalyzed by ZrO(2) nanoparticles

Comb Chem High Throughput Screen. 2012 Jun 1;15(5):395-9. doi: 10.2174/138620712800194486.

Abstract

A simple one-pot method for the preparation of 7-amino-2,4-dioxo-5-aryl-1,2,3,4-tetrahydropyrido[2,3- d]pyrimidine-6-carbonitriles 4 from aromatic aldehydes, malononitrile and 4(6)-aminouracil in the presence of ZrO2 nanoparticles (ZrO2 NPs) as an efficient heterogeneous catalyst is described. The procedure has the advantages of high yields (86-97%), short reaction time (2h) and an environmentally friendly specificity.

MeSH terms

  • Catalysis
  • Combinatorial Chemistry Techniques / methods*
  • Nanoparticles / chemistry
  • Nitriles / chemistry
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / chemistry*
  • Solvents / chemistry
  • Uracil / analogs & derivatives
  • Uracil / chemistry
  • Zirconium / chemistry*

Substances

  • Nitriles
  • Pyrimidines
  • Solvents
  • Uracil
  • 5-(4-chlorobenzyl)-6-aminouracil
  • Zirconium
  • dicyanmethane
  • zirconium oxide