Imaging the sialome during zebrafish development with copper-free click chemistry

Chembiochem. 2012 Feb 13;13(3):353-7. doi: 10.1002/cbic.201100649. Epub 2012 Jan 20.

Abstract

The sialome comprises sialylated glycoproteins and glycolipids that play essential roles in cell-cell communication. Using azide-modified molecular precursors of sialic acids and copper-free click chemistry, we visualized the spatiotemporal dynamics of the sialome in live zebrafish embryos.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Click Chemistry*
  • Copper
  • Glycolipids / analysis*
  • Glycolipids / chemistry
  • Glycolipids / metabolism
  • Sialic Acids / analysis
  • Sialic Acids / chemistry
  • Sialic Acids / metabolism*
  • Staining and Labeling*
  • Zebrafish / embryology*
  • Zebrafish / metabolism*
  • Zebrafish Proteins / analysis*
  • Zebrafish Proteins / chemistry
  • Zebrafish Proteins / metabolism

Substances

  • Glycolipids
  • Sialic Acids
  • Zebrafish Proteins
  • Copper