Evaluation of the efficacy of two mouthrinses formulated for the relief of xerostomia of diverse origin in adult subjects

Gerodontology. 2012 Jun;29(2):e1103-12. doi: 10.1111/j.1741-2358.2012.00626.x. Epub 2012 Jan 20.

Abstract

Objective: To evaluate the efficacy of two new mouthrinses in the reduction of xerostomía-associated symptomatology.

Background: Xerostomia is a common chronic health condition that affects a great number of adults and significantly deteriorates quality of life, such that treatment is necessary.

Materials and methods: Sixty-seven adult subjects of both sexes presenting xerostomia of diverse origin were selected. Mouthrinses were tested using a double-blind, randomized, cross-over clinical trial with an intervining wash out period.

Results: The 100% of subjects presented sensation of dry mouth, and 86% stated sensation of thick saliva. Burning tongue sensation, need to drink liquids to swallow and the sensation of swallowing difficulty were recorded in more than 50% of the patients. The most frequent pathologies in the sample were depression, arthritis, and arterial hypertension. Results of the clinical tests showed that mouthrinse 1 relieves sensation of dry mouth, need to drink liquids, and swallowing difficulty. In contrast, mouthrinse 2 relieves only latter two symptoms. Both rinses were more effective in relieving xerostomía-associated symptomatology in patients taking 3 or more medicines simultaneously.

Conclusion: Both mouthrinses were effective in relieving various xerostomia symptoms, could be distributed at a low cost, thereby improving the quality of life of population affected.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aloe
  • Arthritis / drug therapy
  • Burning Mouth Syndrome / prevention & control
  • Cetylpyridinium / analysis
  • Citric Acid / analysis
  • Cross-Over Studies
  • Deglutition / drug effects
  • Deglutition Disorders / prevention & control
  • Depression / drug therapy
  • Double-Blind Method
  • Female
  • Flavoring Agents / analysis
  • Glycerol / analysis
  • Humans
  • Hypertension / drug therapy
  • Male
  • Mentha spicata
  • Middle Aged
  • Mouthwashes / analysis
  • Mouthwashes / therapeutic use*
  • Propylene Glycol / analysis
  • Saliva / drug effects
  • Saliva / metabolism
  • Secretory Rate / drug effects
  • Sodium Chloride / analysis
  • Sodium Fluoride / analysis
  • Tongue / drug effects
  • Treatment Outcome
  • Xerostomia / prevention & control*
  • Xylitol / analysis

Substances

  • Flavoring Agents
  • Mouthwashes
  • Citric Acid
  • Sodium Chloride
  • Propylene Glycol
  • Sodium Fluoride
  • Cetylpyridinium
  • Glycerol
  • Xylitol