Two male patients, aged 75 and 47 years, suffered from dyspnoea in the terminal phase of their disease, COPD and lung cancer, respectively. Both were given palliative sedation. The palliative consultation team was consulted when problems occurred. Although the Royal Dutch Medical Association issued a guideline on palliative sedation, the practice of administering palliative sedation is still complicated. Determining whether a symptom is 'refractory' and estimating the life expectancy is especially complex. A symptom is refractory when it causes unbearable suffering and conventional modes of treatment are not effective or timely. Knowledge of this guideline, early anticipation of possible scenarios and communication with the patient and his family contribute to good care. The palliative consultation team can help physicians with these decisions, preferably by starting at an early stage.