The purpose of this study was to describe the changes in high-frequency QRS (HF-QRS) components due to myocardial ischemia provoked by prolonged artery occlusion during percutaneous coronary interventions (PCI). Signal-averaged ECGs from 69 patients were obtained during PCI procedures and comparison of high-frequency components of the QRS at different temporal regions and frequency bandwidth were performed. Continuous wavelet transform was applied to estimate the energy contents over the studied time-frequency regions. Seven frequency bands from 50 to 300 Hz, with bandwidth = 100 Hz were considered. The sum of all 12 leads energy decreased significantly (p < 0.001) from pre-PCI to PCI during both second half and total QRS complex in all frequency bands, but the main effect was found in the 200-300 Hz band. The energy changes were more marked toward higher frequency bands. The second half of QRS complex was more sensitive to changes due to myocardial ischemia.