The effect of antioxidant supplementation on fatigue during exercise: potential role for NAD+(H)

Nutrients. 2010 Mar;2(3):319-29. doi: 10.3390/nu2030319. Epub 2010 Mar 10.

Abstract

This study compared serum pyridine levels (NAD(+)/NADH) in trained (n = 6) and untrained (n = 7) subjects after continuous progressive exercise at 50%, 70% then 95% of physical work capacity until fatigue (TTF) after consuming a placebo or antioxidant (AO) cocktail (Lactaway(©)). An increase of 17% in TTF was observed in AO as compared to placebo (p = 0.032). This was accompanied by a significant increase in serum NAD(+) levels (p = 0.037) in the AO supplemented group post exercise. The increases in NAD(+) and improved endurance reflect lower oxidative stress-induced suppression of aerobic respiration.

Keywords: NAD+; NADH; antioxidant; exercise; oxidative stress.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Double-Blind Method
  • Exercise Test
  • Fatigue / metabolism
  • Fatigue / physiopathology
  • Flavonoids / pharmacology*
  • Humans
  • Male
  • Oxidative Stress / drug effects
  • Physical Endurance / drug effects*
  • Plant Extracts
  • Platelet Aggregation Inhibitors / pharmacology*
  • Pyridines / blood*
  • Treatment Outcome

Substances

  • Flavonoids
  • Plant Extracts
  • Platelet Aggregation Inhibitors
  • Pyridines
  • pycnogenols