Abstract
The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Biological Transport / genetics
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Biological Transport / physiology
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Cell Membrane / metabolism
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GTPase-Activating Proteins / chemistry*
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GTPase-Activating Proteins / genetics
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GTPase-Activating Proteins / metabolism
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GTPase-Activating Proteins / physiology*
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Humans
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Microtubule-Associated Proteins / chemistry*
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Microtubule-Associated Proteins / genetics
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Microtubule-Associated Proteins / metabolism
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Microtubule-Associated Proteins / physiology*
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Models, Biological
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Protein Interaction Domains and Motifs / genetics
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Protein Interaction Domains and Motifs / physiology
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Research / trends
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Structure-Activity Relationship
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Teaching
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rho GTP-Binding Proteins / chemistry
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rho GTP-Binding Proteins / genetics
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rho GTP-Binding Proteins / metabolism
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rho GTP-Binding Proteins / physiology
Substances
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GTPase-Activating Proteins
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Microtubule-Associated Proteins
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rho GTP-Binding Proteins