Illuminating the functional and structural repertoire of human TBC/RABGAPs

Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):67-73. doi: 10.1038/nrm3267.

Abstract

The Tre2-Bub2-Cdc16 (TBC) domain-containing RAB-specific GTPase-activating proteins (TBC/RABGAPs) are characterized by the presence of highly conserved TBC domains and act as negative regulators of RABs. The importance of TBC/RABGAPs in the regulation of specific intracellular trafficking routes is now emerging, as is their role in different diseases. Importantly, TBC/RABGAPs act as key regulatory nodes, integrating signalling between RABs and other small GTPases and ensuring the appropriate retrieval, transport and delivery of different intracellular vesicles.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biological Transport / genetics
  • Biological Transport / physiology
  • Cell Membrane / metabolism
  • GTPase-Activating Proteins / chemistry*
  • GTPase-Activating Proteins / genetics
  • GTPase-Activating Proteins / metabolism
  • GTPase-Activating Proteins / physiology*
  • Humans
  • Microtubule-Associated Proteins / chemistry*
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism
  • Microtubule-Associated Proteins / physiology*
  • Models, Biological
  • Protein Interaction Domains and Motifs / genetics
  • Protein Interaction Domains and Motifs / physiology
  • Research / trends
  • Structure-Activity Relationship
  • Teaching
  • rho GTP-Binding Proteins / chemistry
  • rho GTP-Binding Proteins / genetics
  • rho GTP-Binding Proteins / metabolism
  • rho GTP-Binding Proteins / physiology

Substances

  • GTPase-Activating Proteins
  • Microtubule-Associated Proteins
  • rho GTP-Binding Proteins

Associated data

  • PDB/2G77