Abstract
To develop novel inhibitors of ketol-acid reductoisomerase, a series of (oxdi/tri)azoles derivatives was synthesized and characterized by (1)H NMR, MS, elemental analyses, and crystallography. According to the biological activities of these compounds obtained both in vivo and in vitro, compound 4-cyclopropyl-3-((4-fluorobenzyl)thio)-5-methyl-4H-1,2,4-triazole showed excellent KARI inhibitory activity (100% at 100 μg mL (-1) in vitro). In addition, most of the title compounds exhibited good herbicidal activity against Brassica campestris in vivo.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Azoles / chemical synthesis*
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Azoles / chemistry
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Azoles / pharmacology
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Brassica / drug effects
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Brassica / growth & development
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Echinochloa / drug effects
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Echinochloa / growth & development
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / chemistry
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Enzyme Inhibitors / pharmacology
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Herbicides / chemical synthesis*
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Herbicides / chemistry
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Herbicides / pharmacology
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Ketol-Acid Reductoisomerase / antagonists & inhibitors*
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Molecular Structure
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Plant Roots / drug effects
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Plant Roots / growth & development
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Seedlings / drug effects
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Seedlings / growth & development
Substances
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Azoles
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Enzyme Inhibitors
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Herbicides
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Ketol-Acid Reductoisomerase