A synthetic C34 trimer of HIV-1 gp41 shows significant increase in inhibition potency

ChemMedChem. 2012 Feb 6;7(2):205-8. doi: 10.1002/cmdc.201100542. Epub 2012 Jan 13.

Authors

Wataru Nomura¹, Chie Hashimoto, Aki Ohya, Kosuke Miyauchi, Emiko Urano, Tomohiro Tanaka, Tetsuo Narumi, Toru Nakahara, Jun A Komano, Naoki Yamamoto, Hirokazu Tamamura

Affiliation

¹ Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.

PMID: 22247043
DOI: 10.1002/cmdc.201100542

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Anti-HIV Agents / pharmacology
Cell Line
HIV Envelope Protein gp41 / antagonists & inhibitors*
HIV Envelope Protein gp41 / chemical synthesis
HIV Envelope Protein gp41 / chemistry
HIV Envelope Protein gp41 / metabolism
HIV Envelope Protein gp41 / pharmacology
HIV Fusion Inhibitors / chemical synthesis*
HIV Fusion Inhibitors / chemistry
HIV Fusion Inhibitors / pharmacology
HIV-1 / drug effects*
HIV-1 / metabolism
Humans
Peptide Fragments / chemical synthesis
Peptide Fragments / chemistry*
Peptide Fragments / pharmacology*
Protein Multimerization

Substances

Anti-HIV Agents
HIV Envelope Protein gp41
HIV Fusion Inhibitors
Peptide Fragments
peptide C34