Quetiapine-induced frequent premature ventricular contraction

Abstract

A 17-year-old female diagnosed with bipolar II disorder was treated for emotional lability with quetiapine. Two-lead electrocardiography revealed frequent monomorphic premature ventricular contraction (PVC) during an electroencephalography examination. Twenty-four-hour Holter electrocardiography revealed 0.6% uniform frequent PVCs and indicated that the readministration and second-time withdrawal of quetiapine markedly increased (7.1%) and decreased the frequency of PVC (1.1%), respectively. This case indicates that quetiapine can cause PVC as a serious side effect.