Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

John A Hayes; Kevin S Eccles; Simon E Lawrence; Humphrey A Moynihan

doi:10.1016/j.carres.2011.12.018

Preparation and characterisation of solid state forms of paracetamol-O-glucuronide

Carbohydr Res. 2012 Feb 15:349:108-12. doi: 10.1016/j.carres.2011.12.018. Epub 2011 Dec 29.

Authors

John A Hayes¹, Kevin S Eccles, Simon E Lawrence, Humphrey A Moynihan

Affiliation

¹ Department of Chemistry/Analytical and Biological Chemistry Research Facility, University College Cork, College Road, Cork, Ireland.

PMID: 22244339
DOI: 10.1016/j.carres.2011.12.018

Abstract

The synthesis and crystallisation of the pharmaceutically important metabolite, paracetamol-O-glucuronide, is described. Hydrated and anhydrous forms of the target molecule have been characterised by PXRD, DSC and TGA. In addition, a methanol solvate has been analysed, including single crystal analysis, which represents the first structure solution for this system.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acetaminophen / chemical synthesis*
Acetaminophen / chemistry*
Carbohydrate Conformation
Glucuronides / chemical synthesis*
Glucuronides / chemistry*
Models, Molecular

Substances

Glucuronides
Acetaminophen