Abstract
2-(2-Phenylethyl) chromones and a 2-(2-phenylethenyl) chromone, were isolated from the ethanolic extract of Chinese eaglewood. Their structures were determined on the basis of extensive analyses of spectroscopic data. Among those, one showed significant neuroprotective activities against both glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells at a concentration of 10 μM and increased cell viability by 82.2% and 86.9%, respectively.
Copyright © 2011 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Survival
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Chromones / chemistry*
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Chromones / isolation & purification
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Chromones / pharmacology*
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Corticosterone / adverse effects
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Ethanol / chemistry
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology
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Glutamic Acid / adverse effects
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Humans
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Magnetic Resonance Spectroscopy
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Molecular Structure
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Neuroprotective Agents / chemistry
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Neuroprotective Agents / isolation & purification*
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Neuroprotective Agents / pharmacology
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PC12 Cells
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Rats
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Thymelaeaceae / chemistry*
Substances
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6,8-dihydroxy-2-(2-(3'-hydroxy-4'-methoxyphenyl)ethyl)chromone
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Chromones
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Drugs, Chinese Herbal
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Flavonoids
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Neuroprotective Agents
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6,7-dimethoxy-2-(2-(4-methoxyphenyl)ethyl)chromone
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Ethanol
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Glutamic Acid
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2-(2-phenylethyl)chromone
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Corticosterone