Homocysteine is an intermediate metabolite of methionine metabolism. Hyperhomocysteinemia which is caused by abnormal homocysteine metabolism has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis, chronic kidney disease. In this paper, we first briefly introduced hyperhomocysteinemia and its pathogenesis, then summarized the treatment advances of hyperhomocysteinemia using folic acid, vitamin B6, B12, betaine, atorvastatin, isoflavones, taurine and some Chinese traditional medicine. Finally, the potential problems of the various treatment methods were analyzed.