The hyperkinekic effect (increase in spontaneous activity and development of choreomyoclonic hyperkinesis of the extremities and body) of picrotoxin injected into the rostral neostriatum of rats in a dose of 2 μg was reduced if the drug was injected together with ZnCl(2) in a concentration of 0.1 μg/μl. ZnCl(2) in a concentration of 1 μg/μl did not modulate the effects of picrotoxin, while in a concentration of 3 μg/μl it increased spontaneous motor activity in the open field test without affecting the symptoms of choreomyoclonic hyperkinesis.