Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process

V V Sobolev; A D Zolotorenko; A G Soboleva; A M Elkin; S A Il'ina; D N Serov; N N Potekaev; S B Tkachenko; M T Minnibaev; A L Piruzyan

doi:10.1007/s10517-011-1208-0

Effects of expression of transcriptional factor AP-1 FOSL1 gene on psoriatic process

Bull Exp Biol Med. 2011 Mar;150(5):632-4. doi: 10.1007/s10517-011-1208-0.

Authors

V V Sobolev¹, A D Zolotorenko, A G Soboleva, A M Elkin, S A Il'ina, D N Serov, N N Potekaev, S B Tkachenko, M T Minnibaev, A L Piruzyan

Affiliation

¹ N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia.

PMID: 22235402
DOI: 10.1007/s10517-011-1208-0

Abstract

We performed quantitative analysis of FOSL1 gene expression in lesional psoriatic skin. The expression of this gene in lesional psoriatic skin was significantly increased compared to that in unaffected areas. Enhanced FOSL1 expression significantly correlated with high psoriasis area and severity index (PASI). High level of FOSL1 gene expression was proposed to be a marker of pathological process activity in psoriasis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Humans
Proto-Oncogene Proteins c-fos / metabolism*
Psoriasis / genetics*
Psoriasis / pathology*
RNA, Messenger / genetics
RNA, Messenger / metabolism
Skin / metabolism
Skin / pathology*
Transcription Factor AP-1 / metabolism*

Substances

Proto-Oncogene Proteins c-fos
RNA, Messenger
Transcription Factor AP-1
fos-related antigen 1