A copper-based catalytic system for carboxylation of terminal alkynes: synthesis of alkyl 2-alkynoates

Org Biomol Chem. 2012 Feb 28;10(8):1514-6. doi: 10.1039/c2ob06884b. Epub 2012 Jan 11.

Abstract

An efficient coupling of terminal alkynes and CO(2) in the presence of alkyl halides can be achieved under ambient conditions using a copper/phosphine catalyst system, providing facile access to a variety of functionalised alkyl 2-alkynoates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbon Dioxide / chemistry
  • Catalysis
  • Copper / chemistry*
  • Molecular Structure

Substances

  • Alkynes
  • Carbon Dioxide
  • Copper