Recent advances in stealth coating of nanoparticle drug delivery systems

Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2012 Mar-Apr;4(2):219-33. doi: 10.1002/wnan.1157. Epub 2012 Jan 9.

Abstract

Modifying surfaces of nanoparticles (NPs) with polyethylene glycol (PEG), the so-called PEGylation, is the most commonly used method for reducing premature clearance of NPs from the circulation. However, several reports point out that PEGylation may negatively influence the performance of NPs as a drug carrier. Alternative surface modification strategies, including substitute polymers, conditional removal of PEG, and biomimetic surface modification, may provide solutions for the limitations of PEG.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Coated Materials, Biocompatible / chemistry*
  • Drug Delivery Systems / methods*
  • Drug Delivery Systems / trends*
  • Nanoparticles / chemistry*
  • Polyethylene Glycols / chemistry*
  • Surface Properties

Substances

  • Coated Materials, Biocompatible
  • Polyethylene Glycols