OA in 2011: Age-related OA--a concept emerging from infancy?

Nat Rev Rheumatol. 2012 Jan 10;8(2):70-2. doi: 10.1038/nrrheum.2011.206.

Abstract

That primary osteoarthritis (OA) is an age-related disorder is undoubted, but how aging contributes to OA is poorly understood. New insights from 2011 offer potential explanations, novel models for study, and the suggestion that a deeper understanding of what 'aging' actually is might pave the way to everlasting joints.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Aging / pathology*
  • Aging / physiology
  • Animals
  • Cartilage, Articular / pathology
  • Cartilage, Articular / physiopathology
  • Cell Death
  • Cellular Senescence / physiology
  • Disease Models, Animal
  • Humans
  • Joints / pathology
  • Joints / physiopathology
  • Mice
  • Osteoarthritis* / etiology
  • Osteoarthritis* / pathology
  • Osteoarthritis* / physiopathology
  • Oxidative Stress