Abstract
That primary osteoarthritis (OA) is an age-related disorder is undoubted, but how aging contributes to OA is poorly understood. New insights from 2011 offer potential explanations, novel models for study, and the suggestion that a deeper understanding of what 'aging' actually is might pave the way to everlasting joints.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aging / pathology*
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Aging / physiology
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Animals
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Cartilage, Articular / pathology
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Cartilage, Articular / physiopathology
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Cell Death
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Cellular Senescence / physiology
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Disease Models, Animal
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Humans
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Joints / pathology
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Joints / physiopathology
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Mice
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Osteoarthritis* / etiology
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Osteoarthritis* / pathology
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Osteoarthritis* / physiopathology
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Oxidative Stress