Attempts to predict changes in Atlantic Meridional Overturning Circulation (AMOC) have yielded little success to date. Here, we demonstrate predictability for monthly mean AMOC strength at 26.5°N for up to 4 years in advance. This AMOC predictive skill arises predominantly from the basin-wide upper-mid-ocean geostrophic transport, which in turn can be predicted because we have skill in predicting the upper-ocean zonal density difference. Ensemble forecasts initialized between January 2008 and January 2011 indicate a stable AMOC at 26.5°N until at least 2014, despite a brief wind-induced weakening in 2010. Because AMOC influences many aspects of climate, our results establish AMOC as an important potential carrier of climate predictability.