Conjugated polymers for light-activated antifungal activity

Chengfen Xing; Gaomai Yang; Libing Liu; Qiong Yang; Fengting Lv; Shu Wang

doi:10.1002/smll.201101825

Conjugated polymers for light-activated antifungal activity

Small. 2012 Feb 20;8(4):524-9. doi: 10.1002/smll.201101825. Epub 2012 Jan 5.

Authors

Chengfen Xing¹, Gaomai Yang, Libing Liu, Qiong Yang, Fengting Lv, Shu Wang

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P.R. China.

PMID: 22223534
DOI: 10.1002/smll.201101825

Abstract

A cationic polythiophene-porphyrin (PTP) dyad is shown to exhibit efficient light-activated antifungal activity. Higher singlet oxygen (¹O₂) generation efficiency can be attained from PTP upon photoexcitation due to the light-harvesting properties of the polymer backbone and efficient energy transfer from the polythiophene to the porphyrin units. PTP can be used for treating fungal infections in lower doses of irradiation light and polymer concentration.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
Aspergillus niger / drug effects*
Aspergillus niger / radiation effects
Aspergillus niger / ultrastructure
Energy Transfer / drug effects
Light*
Microbial Sensitivity Tests
Polymers / chemistry
Polymers / pharmacology*
Porphyrins / chemistry
Porphyrins / pharmacology
Thiophenes / chemistry
Thiophenes / pharmacology

Substances

Antifungal Agents
Polymers
Porphyrins
Thiophenes
polythiophene